Therapeutic Effects of Toxoplasma Lysate Antigen on 20-Methylcholanthrene-Induced BALB/c Mouse Tumors.

• DOI: 10.1292/jvms.54.7
• Publication Date: 2011-08-16T06:05:23Z
• Authors: Kazuro MIYAHARA; Uriko HONDA; Shinichi TOSE; Haruhisa SAKURAI; Ikuo IGARASHI; Atsushi SAITO; Tsuneo HIROSE; Naoyoshi SUZUKI
• Keywords: Methylcholanthrene

Therapeutic effects of Toxoplasma lysate antigen (TLA) were studied in mice bearing the tumor second passage 20-methylcholanthrene (MC)-induced cells. Intramuscular administration TLA 7 days after tumor-cell inoculation caused apparent inhibition growth on day 14. The treatment facilitated therapeutic effects. Intravenous transfer spleen cells prepared from TLA-sensitized into tumor-bearing also represented inhibitory Prominent seen when transferred 5 sensitization donor animals. absent groups only adherent or non-adherent sensitized mice. strongest effect was observed group to which both and simultaneously In vitro experiments, obtained showed cytolytic P-815 YAC-1 secondary stimulation with TLA. Large containing densely packed granules induced cultured These results revealed that can inhibit chemically-induced transplantable tumors by activation