Contrast-Enhanced MRI with Gadodiamide Injection in Rabbit Carcinoma Models.

• DOI: 10.1292/jvms.58.389
• Publication Date: 2011-08-16T06:10:01Z
• Authors: Kazutaka YAMADA; Takeshi JINBO; Kazuro MIYAHARA; Motoyoshi SATO; Tsuneo HIROSE; Hirotoshi KATO; Yukio TATENO; Hiroo IKEHIRA; Hiroshi SUGIHARA; Kazuhisa FURUHAMA
• Keywords: Gadodiamide; Dynamic Contrast-Enhanced MRI

This study was designed to demonstrate the broad utility of contrast-enhanced magnetic resonance imaging (MRI) for diagnosis carcinoma. Twenty-six New Zealand White rabbits either sex (1.7-3.4 kg) were used investigation. VX2 carcinoma (squamous cell carcinoma) implanted in brain, lung, ovary, bone or muscle rabbits. Contrast agent, Gadodiamide Injection, administered intravenously at a dose 0.1 mmol/kg. MR images obtained by 1.5 T, 2.0 T field strength super-conductive MRI unit. The intensity signal increased after administration contrast and detectability diagnostic information post-contrast superior that pre-contrast all models. In addition, no significant side effects observed during examination. After using MRI, morphological damage each model assessed gross histopathological examinations. though there variations between models employed, brain generally related differences capillary permeability, while ovary dependent on blood flow rate size interstitial spaces. Overall, our results is useful safe method diagnosing tumors.