Effects of DDAVP Administrated Subcutaneously in Dogs with Aspirin-induced Platelet Dysfunction and Hemostatic Impairment due to Chronic Liver Diseases.

• DOI: 10.1292/jvms.65.83
• Publication Date: 2003-02-07T09:03:28Z
• Authors: Manabu SAKAI; Toshihiro WATARI; Teruhisa MIURA; Haruhiko MARUYAMA; Hiroshi KOIE; Yoshiki YAMAYA; Akira TAKEUCHI; Atsuhiko HASEGAWA
• Keywords: Blood Platelets; Hemostasis; Factor VIII; Aspirin; Injections, Subcutaneous; Liver Diseases; 03 medical and health sciences; Dogs; 0302 clinical medicine; Animals; Deamino Arginine Vasopressin; Blood Platelet Disorders; Dog Diseases; Blood Coagulation

To evaluate the hemostatic effects of desmopressin (DDAVP) in dogs with aspirin-induced platelet dysfunction and hemostatic impairment in chronic liver diseases, 3 microg/kg DDAVP was administrated subcutaneously. In aspirin-induced platelet dysfunction dogs (n=5), prolonged BMBT (buccal mucosal bleeding time) was shortened significantly after DDAVP injection (2.2 +/- 1.2 min, P<0.05). In dogs with chronic liver diseases (n=4), activated partial thromboplastin time (APTT) tended to shorten by 0.9 to 3.0 sec, and prolonged BMBT was shortened in two cases for 4.2 and 1.7 min after DDAVP injection. Therefore, the present results indicated that DDAVP shortened the prolonged BMBT in dogs with aspirin-induced platelet dysfunction and chronic liver disease. DDAVP might be helpful in hemostasis under invasive procedures such as biopsy or surgery for dogs with hemostatic impairment.