Minocycline protects against acrylamide-induced neurotoxicity and testicular damage in Sprague-Dawley rats

• DOI: 10.1293/tox.2019-0066
• Publication Date: 2020-02-23T22:03:57Z
• Authors: Khaled Radad; Yassmin El Amir; Ahmed Al-Emam; Mubarak Al-Shraim; Ismaeel Bin-Jaliah; Christopher Krewenka; Rudolf Moldzio
• Keywords: Minocycline; Neurotoxicity; Malondialdehyde

This study investigated the protective effects of minocycline against acrylamide (ACR)-induced neurotoxicity and testicular damage in Sprague-Dawley rats. Forty rats were divided into five groups (eight each). Group I received saline (0.5 mL/rat) daily for 10 days served as untreated control group. II ACR (30 mg/kg body weight (b.w.)) days. III b.w.) subsequently (60 IV followed by group ACR-minocycline-treated V All treatments administered orally. Rats showed normal locomotor behavior histology brain testes. Administration (Group IV) resulted loss gait abnormalities. Furthermore, neuronal degeneration hippocampus cerebellum seminiferous tubular epithelium with formation spermatid giant cells observed. Ultrastructurally, specifically damaged spermatogonia spermatocytes. Acrylamide was also seen to cause a significant increase malondialdehyde levels Treatment ACR-administered III) significantly alleviated improved function. Minocycline ameliorated decreased concentrations. In conclusion, protects neurotoxic damage. Decreasing lipid peroxidation might play role such protection.