A pilot study of regenerative therapy by implanting synovium-derived mesenchymal stromal cells in equine osteochondral defect models

• DOI: 10.1294/jes.29.117
• Publication Date: 2018-12-26T22:27:24Z
• Authors: Atsushi YAMASAKI; Takaya OMURA; Daiki MURATA; Minoru KOBAYASHI; Takafumi SUNAGA; Kanichi KUSANO; Yoshiharu UENO; Tomohide KURAMOTO; Seiji HOBO; Kazuhiro MISUMI
• Keywords: Carpal Joint; Radiodensity; Capsule

Synovium-derived mesenchymal stromal cells (SM-MSCs) from seven Thoroughbreds with naturally occurring intra-articular fracture proliferated to over ten million by the second passage. Using three experimental Thoroughbreds, columnar osteochondral defects were made arthroscopically at bilateral distal radius. Five allogenic SM-MSCs implanted into right defect, and another five injected radio-carpal joint (implantation site). No left defect or same (control At 3 6 weeks after surgery, autologous joints. Radiolucent volumes of calculated analysis postmortem CT images 9 surgery decreased in sites compared control all horses. The average scores for ICRS gross histopathological grading scales equal higher than those controls. These results suggest that implantation subsequent injection might not obstruct subchondral bone formation defects.