The Diagnostic Utility ofp16FISH and GLUT-1 Immunohistochemical Analysis in Mesothelial Proliferations

• DOI: 10.1309/ajcpp5r2zjzkclwn
• Publication Date: 2011-03-16T19:39:51Z
• Authors: Sara E. Monaco; Yongli Shuai; Mona Bansal; Alyssa M. Krasinskas; Sanja Dacic
• Keywords: Adult; Aged, 80 and over; Male; Mesothelioma; 0301 basic medicine; Glucose Transporter Type 1; Adolescent; Genes, p16; Pleural Neoplasms; Middle Aged; Immunohistochemistry; Epithelium; Young Adult; 03 medical and health sciences; Predictive Value of Tests; Humans; Female; Gene Deletion; In Situ Hybridization, Fluorescence; Peritoneal Neoplasms; Aged; Cell Proliferation

Two promising ancillary tests used in the diagnosis of mesothelioma include GLUT-1 immunohistochemical analysis and fluorescence situ hybridization (FISH) testing for p16 deletion. This study compared diagnostic usefulness FISH mesothelial proliferations 158 cases with a benign (45.4%), atypical (10.4%), or malignant/mesothelioma (44.2%). Of 70 cases, none had deletion 5 (7%) were positive GLUT-1. 68 mesotheliomas, 40 (59%) (sensitivity, 59%; specificity, 100%) 27 (40%) 40%; 93%). showed lower sensitivity pleural (56% vs 70%) peritoneal (29% 51%) mesotheliomas (P = .004). Our results demonstrate that is more sensitive specific test than can be reliable tool to support mesothelioma.