Anti–Glomerular Basement Membrane Glomerulonephritis

• DOI: 10.1309/nptp4ukv7ju3elmq
• Publication Date: 2008-07-17T21:03:48Z
• Authors: Edgar G. Fischer; Donna J. Lager
• Keywords: Rapidly progressive glomerulonephritis

Anti-glomerular basement membrane (anti-GBM) glomerulonephritis is a rare disease caused by IgG autoantibodies against the glomerular membrane. We describe clinical and pathologic findings in series of renal biopsy specimens from 80 patients. The patients ranged age 16 to 87 years. distribution was bimodal, with one peak at young predominated males second sixth eighth decades females predominating. Most (70 [88%]) had severe necrotizing crescents more that 50% glomeruli. fraction crescentic glomeruli correlated well serum creatinine levels but not serologic titers for anti-GBM antibodies. Interstitial fibrosis uncommon and, when present, minimal mild. Linear deposition defines this entity, immunofluorescent costaining other immunoglobulins complement found frequently. To our knowledge, largest studied date.