Peptide-based antifungal therapies against emerging infections

• DOI: 10.1358/dof.2010.35.3.1452077
• Publication Date: 2023-04-06T13:51:52Z
• Authors: Matejuk, A.; Leng, Q.; Begum, M.D.; Woodle, M.C.; Scaria, P.; Chou, S.-T.; Mixson, A.J.
• Keywords: Antifungal drugs; Antifungal drugs

Acquired drug resistance to mycotic infections is rapidly emerging as a major medical problem.Opportunistic fungal create therapeutic challenges, particularly in high risk immunocompromised patients with AIDS, cancer, and those undergoing transplantation.Higher mortality and/or morbidity rates due invasive mycosis have been increasing over the last 20 years, light of growing commonly used antibiotics, novel antifungal drugs approaches are required.Currently there considerable interest peptides that ubiquitous plant animal kingdoms.These small cationic may specific targets or be multifunctional their mechanism action.On basis recent advances protein engineering solid phase syntheses, utility potential selected efficient acceptable toxicity profiles being realized.This review will discuss peptide therapy for opportunistic infections.