Analysis of low-scattering regions in optical coherence tomography: applications to neurography and lymphangiography

• DOI: 10.1364/boe.10.004207
• Publication Date: 2019-07-26T15:54:31Z
• Authors: Valentin Demidov; Lev A. Matveev; Olga Demidova; Alexander L. Matv...; Vladimir Y. Zaitsev; Costel Flueraru; I. Alex Vitkin
• Keywords: Magnetic resonance neurography

Analysis of semi-transparent low scattering biological structures in optical coherence tomography (OCT) has been actively pursued the context lymphatic imaging, with most approaches relying on relative absence signal as a means detection. Here we present an alternate methodology based spatial speckle statistics, utilizing similarity distribution given voxel intensities to power function pure noise, visualize low-scattering interest. In human tumor xenograft murine model, show that these correspond vessels and nerves; extensive histopathologic validation studies are reported unequivocally establish this correspondence. The emerging possibility OCT lymphangiography neurography is novel potentially impactful (especially latter), although further refinement needed distinguish between visualized lymphatics nerves.