Functional imaging of the human brain using a modular, fibre-less, high-density diffuse optical tomography system

• DOI: 10.1364/boe.7.004275
• Publication Date: 2016-09-27T14:14:54Z
• Authors: Danial Chitnis; Robert J. Cooper; Laura Dempsey; Samuel Powell; Simone Quaggia; David Highton; Clare Elwell; Jeremy C. Hebden; Nicholas L. Everdell
• Keywords: Diffuse optical imaging; Optical Tomography

We present the first three-dimensional, functional images of human brain to be obtained using a fibre-less, high-density diffuse optical tomography system. Our technology consists independent, miniaturized, silicone-encapsulated DOT modules that can placed directly on scalp. Four these were arranged provide up 128, dual-wavelength measurement channels over scalp area approximately 60 × 65 mm2. Using series motor-cortex stimulation experiments, we demonstrate this system obtain high-quality, continuous-wave measurements at source-detector separations ranging from 14 55 mm in adults, presence hair. identify robust haemodynamic response functions 5 out subjects, and depict responses are well-localized all three dimensions both individual group levels. This prototype modular paves way for new generation wearable, wireless, neuroimaging technologies.