Imaging DNA damage-dependent chromatin dynamics via nonlinear photoperturbation

• DOI: 10.1364/cleo_si.2013.ctu2m.6
• Publication Date: 2013-06-26T11:20:27Z
• Authors: M. Tomas; P. Blumhardt; A. Deutzmann; D. Kromm; A. Leitenstorfer; E. Ferrando-May
• Keywords: 0301 basic medicine; 03 medical and health sciences

We employ near-infrared femtosecond pulses to probe local alterations of chromatin dynamics caused by DNA strand breaks. Nonlinear confocal nanomanipulation enables us to visualize how DNA damage signaling emanates spatio-temporally in a live cell.