Highly biocompatible amphiphilic perylenediimide derivative for bioimaging

• DOI: 10.1364/ome.6.001420
• Publication Date: 2016-04-04T16:13:58Z
• Authors: Jin-Kyung Park; Ran Hee Kim; Prem Prabhakaran; Sehoon Kim; Kwang-Sup Lee
• Keywords: Biocompatibility; Biocompatible material

We report the synthesis and biological studies of a fluorescence dye with an oligoethylene glycol substituted (OEG) perylene centered N,N’-(2,6-diisopropylphenyl)-1-[oligo(ethylene glycol)methyl ether]-1,6,7,12-trichloroperylene-3,4:9,10-tetracarboxdiimide (PDI-OEG). The activity is juxtaposed precursor molecule without OEG substitution. substitution contributes to increased biocompatibility PDI-OEG. Cell viability lead survival more than 80% PDI-OEG cultured cells endorsing its biocompatibility. Fluorescence imaging were carried out using multiple cell lines. Ex-vivo involving nude mice used establish liver lung specific organ targeting This fluorophore excellent example stable biocompatible red emitting small for bioimaging.