Correction: Significant CD4, CD8, and CD19 Lymphopenia in Peripheral Blood of Sarcoidosis Patients Correlates with Severe Disease Manifestations

• DOI: 10.1371/annotation/a75007e1-492a-4bcb-80a8-28b4d432c099
• Publication Date: 2014-03-12T17:00:59Z
• Authors: Nadera J. Sweiss; Rafah Salloum; Seema Gandhi; Maria-Luisa Alegre; Ray Sawaqed; Maria Badaracco; Kenneth Pursell; David Pitrak; Robert P. Baughman; David R. Moller; Joe G. N. Garcia; Timothy B. Niewold
• Keywords: 03 medical and health sciences; 0302 clinical medicine; Science; Q; R; Medicine; Correction

Background: Sarcoidosis is a poorly understood chronic inflammatory condition.Infiltration of affected organs by lymphocytes characteristic sarcoidosis, however previous reports suggest that circulating lymphocyte counts are low in some patients with the disease.The goal this study was to evaluate subsets peripheral blood cohort sarcoidosis determine prevalence, severity, and clinical features associated lymphopenia major subsets.Methodology/Principal Findings: Lymphocyte 28 sarcoid were analyzed using flow cytometry percentage CD4, CD8, CD19 positive cells.Greater than 50% had abnormally or (p,4610 210 ).Lymphopenia profound cases, five absolute CD4 below 200.CD4, subset significantly correlated (Spearman's rho 0.57, p = 0.0017), 10 all three subsets.Patients severe organ system involvement including neurologic, cardiac, ocular, advanced pulmonary disease lower as group those less manifestations (CD4 0.0043, CD8 0.026, 0.033).No significant relationships observed between various medical therapies counts, present who not receiving any therapy.Conclusions/Significance: Significant involving cells common severity.Our findings relates more pathology treatment.