Population Genomics: Whole-Genome Analysis of Polymorphism and Divergence in Drosophila simulans

• DOI: 10.1371/journal.pbio.0050310
• Publication Date: 2007-10-30T18:33:04Z
• Authors: David J Begun; Alisha K Holloway; Kristian Stevens; LaDeana W Hillier; Yu-Ping Poh; Matthew W Hahn; Phillip M Nista; Corbin D Jones; Andrew D Kern; Colin N Dewey; Lior Pachter; Eugene Myers; Charles H Langley
• Keywords: Population genomics; Comparative Genomics

The population genetic perspective is that the processes shaping genomic variation can be revealed only through simultaneous investigation of sequence polymorphism and divergence within between closely related species. Here we present a analysis Drosophila simulans based on whole-genome shotgun sequencing multiple inbred lines comparison resulting data to genome assemblies species, D. melanogaster yakuba. We discovered previously unknown, large-scale fluctuations along chromosome arms, significantly less faster X chromosome. generated comprehensive list functional elements in influenced by adaptive evolution. Finally, characterized patterns base composition for coding noncoding sequence. These results suggest several new hypotheses regarding biological mechanisms controlling across genome, provide rich resource evolution simulans.