The Wnt Pathway Controls Cell Death Engulfment, Spindle Orientation, and Migration through CED-10/Rac

• DOI: 10.1371/journal.pbio.1000297
• Publication Date: 2010-02-01T22:55:08Z
• Authors: Juan Cabello; Lukas J. Neukomm; Ufuk Günesdogan; Katharina Burkart; Steve J. Charette; Günter Lochnit; Michael O. Hengar...; Ralf Schnabel
• Keywords: Cell polarity

Wnt signalling pathways have extremely diverse functions in animals, including induction of cell fates or tumours, guidance movements during gastrulation, and the polarity. can induce polar changes cellular morphology by a remodelling cytoskeleton. However, how activation Frizzled receptor induces cytoskeleton rearrangement is not well understood. We show, an depth 4-D microscopy analysis, that Caenorhabditis elegans pathway signals to CED-10/Rac via two separate branches regulate modulation different situations. Apoptotic clearance migration distal tip require MOM-5/Fz receptor, GSK-3 kinase, APC/APR-1, which activate CED-2/5/12 branch engulfment machinery. MOM-5 (Frizzled) thus function as C. elegans. Our epistatic analyses also suggest partially redundant defined earlier for may act single early embryos. By contrast, mitotic spindles requires beta-catenins, but downstream factors LIT-1/NLK POP-1/Tcf. Taken together, our results indicate multiple developmental processes, link mediated rearrangements