A Key Commitment Step in Erythropoiesis Is Synchronized with the Cell Cycle Clock through Mutual Inhibition between PU.1 and S-Phase Progression

• DOI: 10.1371/journal.pbio.1000484
• Publication Date: 2010-09-21T19:30:46Z
• Authors: Ramona Pop; Jeffrey R. Shears...; Qichang Shen; Ying Liu; Kelly Hallstrom; Miroslav Koulnis; Joost Gribnau; Merav Socolovsky
• Keywords: DNA Replication; 571; QH301-705.5; Down-Regulation; S Phase; Cell and Developmental Biology; Mice; 03 medical and health sciences; Antigens, CD; Proto-Oncogene Proteins; Receptors, Transferrin; Medicine and Health Sciences; Animals; GATA1 Transcription Factor; Erythropoiesis; Biology (General); Cyclin-Dependent Kinase Inhibitor p57; 0303 health sciences; Cell Cycle; Life Sciences; Cell Differentiation; DNA Methylation; EMC MGC-02-82-01; Chromatin; 3. Good health; Trans-Activators; Research Article

During red blood cell development, differentiation and cycle progression are intimately uniquely linked through interdependent mechanisms involving the erythroid transcriptional suppressor PU.1 cyclin-dependent kinase inhibitor p57KIP2.