Heat Shock Transcription Factor σ32 Co-opts the Signal Recognition Particle to Regulate Protein Homeostasis in E. coli

• DOI: 10.1371/journal.pbio.1001735
• Publication Date: 2013-12-17T21:42:38Z
• Authors: Bentley Lim; Ryoji Miyazaki; Saskia Neher; Deborah A. Siegele; Koreaki Ito; Peter Walter; Yoshinori Akiyama; Takashi Yura; Carol A. Gross
• Keywords: Proteostasis; Heat shock factor; Proteome; Chaperone (clinical); Transport protein

The bacterial heat shock transcription factor, σ32, maintains proper protein homeostasis only after it is targeted to the inner membrane by signal recognition particle (SRP), thereby enabling integration of folding information from both cytoplasm and cell membrane.