Hypoxia-Inducible Factor-2α Is an Essential Catabolic Regulator of Inflammatory Rheumatoid Arthritis

• DOI: 10.1371/journal.pbio.1001881
• Publication Date: 2014-06-10T23:56:47Z
• Authors: Je-Hwang Ryu; Chang-Suk Chae; Ji-Sun Kwak; Hwanhee Oh; Youngnim Shin; Yun Hyun Huh; Choong-Gu Lee; Yong-Wook Park; Churl-Hong Chun; Young-Myeong Kim; Sin-Hyeog Im; Jang-Soo Chun
• Keywords: Hypoxia; Hypoxia-Inducible Factors; Catabolism

Hypoxia-inducible factor-2α (HIF-2α) is sufficient to cause experimental rheumatoid arthritis and acts regulate the functions of fibroblast-like cells from tissue surrounding joints, independent HIF-1α.