Glucotypes reveal new patterns of glucose dysregulation

• DOI: 10.1371/journal.pbio.2005143
• Publication Date: 2018-07-24T18:25:07Z
• Authors: Heather Hall; Dalia Perelman; Alessandra Breschi; Patricia Limcaoco; Ryan Kellogg; Tracey McLaughlin; Michael Snyder
• Keywords: Prediabetes; Blood sugar regulation

Diabetes is an increasing problem worldwide; almost 30 million people, nearly 10% of the population, in United States are diagnosed with diabetes. Another 84 prediabetic, and without intervention, up to 70% these individuals may progress type 2 Current methods for quantifying blood glucose dysregulation diabetes prediabetes limited by reliance on single-time-point measurements or average measures overall glycemia neglect dynamics. We have used continuous monitoring (CGM) evaluate frequency which demonstrate elevations postprandial glucose, types patterns, how patterns vary between given identical nutrient challenge. Measurement insulin resistance secretion highlights fact that physiology underlying dysglycemia highly variable individuals. developed analytical framework can group according specific glycemic responses called "glucotypes" reveal heterogeneity, subphenotypes, within traditional diagnostic categories regulation. Importantly, we found even considered normoglycemic standard exhibit high variability using CGM, levels reaching prediabetic diabetic ranges 15% 2% time, respectively. thus show dysregulation, as characterized more prevalent heterogeneous than previously thought affect measures, reflect physiology. The interindividual standardized meals also personal nature Through extensive phenotyping, a model identifying potential mechanisms built webtool visualizing user-uploaded CGM profile classifying individualized into glucotypes.