Sensitivity analysis of closed-loop one-chamber and four-chamber models with baroreflex

• DOI: 10.1371/journal.pcbi.1012377
• Publication Date: 2024-12-23T18:46:07Z
• Authors: Karolina Tlałka; Harry Saxton; Ian Halliday; Xu Xu; Andrew Narracott; Daniel Taylor; Maciej Malawski
• Keywords: Pulsatile flow

The baroreflex is one of the most important control mechanisms in human cardiovascular system. This work utilises a closed-loop silico model regulation, coupled to pulsatile mechanical models with (i) heart chamber and 36-parameters (ii) four chambers 51 parameters. We perform first global sensitivity analysis these systems which considers both parameters, compare their respective unregulated equivalents. Results show reduced influence regulated parameters compared equivalents that, physiological resting state, outputs (pressures, rate, cardiac output etc.) are sensitive parasympathetic arc provides insight into effects regulation input parameter on clinical metrics, constitutes step understanding role for personalised healthcare.