Genome-Wide Association Study Identifies HLA-DP as a Susceptibility Gene for Pediatric Asthma in Asian Populations

• DOI: 10.1371/journal.pgen.1002170
• Publication Date: 2011-07-21T20:57:27Z
• Authors: Emiko Noguchi; Hiromi Sakamoto; Tomomitsu Hirota; Kaori Ochiai; Yoshimasa Imoto; Masafumi Sakashita; Fumitake Kurosaka; Akira Akasawa; Shigemi Yoshihara; Noriko Kanno; Yumi Yamada; Naoki Shimojo; Yoichi Kohno; Yoichi Suzuki; Mi-Jin Kang; Ji-Won Kwon; Soo-Jong Hong; Ken Inoue; Yu-ichi Goto; Fumio Yamashita; Takashi Asada; Hiroshi Hirose; Ikuo Saito; Shigeharu Fujieda; Nobuyuki Hizawa; Toru Sakamoto; Hironori Masuko; Yusuke Nakamura; Ichiro Nomura; Mayumi Tamari; Tadao Arinami; Teruhiko Yoshida; Hirohisa Saito; Kenji Matsumoto
• Keywords: Linkage Disequilibrium; Genome-wide Association Study; Genetic Association; SNP

Asthma is a complex phenotype influenced by genetic and environmental factors. We conducted genome-wide association study (GWAS) with 938 Japanese pediatric asthma patients 2,376 controls. Single-nucleotide polymorphisms (SNPs) showing strong associations (P<1×10−8) in GWAS were further genotyped an independent samples (818 cases 1,032 controls) Korean (835 421 controls). SNP rs987870, located between HLA-DPA1 HLA-DPB1, was consistently associated 3 populations (Pcombined = 2.3×10−10, odds ratio [OR] 1.40). HLA-DP allele analysis showed that DPA1*0201 DPB1*0901, which linkage disequilibrium, strongly (DPA1*0201: P 5.5×10−10, OR 1.52, DPB1*0901: 2.0×10−7, 1.49). Our findings show variants the locus are risk of Asian populations.