Genome-Wide Association of Body Fat Distribution in African Ancestry Populations Suggests New Loci

• DOI: 10.1371/journal.pgen.1003681
• Publication Date: 2013-08-16T04:21:42Z
• Authors: Ching-Ti Liu; Keri L. Monda; Kira C. Taylor; Leslie Lange; Ellen W. Demerath; Walter Palmas; Mary K. Wojczynski; Jaclyn C. Ellis; Mara Z. Vitolins; Simin Liu; George J. Papanic...; Marguerite R. Irvin; Luting Xue; Paula J. Griffin; Michael A. Nalls; Adebowale Adeyemo; Jiankang Liu; Guo Li; Edward A. Ruiz-Na...; Wei-Min Chen; Fang Chen; Brian E. Henderson; Robert C. Millikan; Christine B. Ambr...; Sara S. Strom; Xiuqing Guo; Jeanette S. Andrews; Yan V. Sun; Thomas H. Mosley; Lisa R. Yanek; Daniel Shriner; Talin Haritunians; Jerome I. Rotter; Elizabeth K. Spel...; Megan Smith; Lynn Rosenberg; Josyf Mychaleckyj; Uma Nayak; Ida Spruill; W. Timothy Garvey; Curtis Pettaway; Sarah Nyante; Elisa V. Bandera; Angela F. Britton; Alan B. Zonderman; Laura J. Rasmusse...; Yii-Der Ida Chen; Jingzhong Ding; Kurt Lohman; Stephen B. Kritch...; Wei Zhao; Patricia A. Peyser; Sharon L. R. Kardia; Edmond Kabagambe; Ulrich Broeckel; Guanjie Chen; Jie Zhou; Sylvia Wasserthei...; Marian L. Neuhouser; Evadnie Rampersaud; Bruce Psaty; Charles Kooperberg; JoAnn E. Manson; Lewis H. Kuller; Heather M. Ochs-B...; Karen C. Johnson; Lara Sucheston; Jose M. Ordovas; Julie R. Palmer; Christopher A. Ha...; Barbara McKnight; Barbara V. Howard; Diane M. Becker; Lawrence F. Bielak; Yongmei Liu; Matthew A. Allison; Struan F. A. Grant; Gregory L. Burke; Sanjay R. Patel; Pamela J. Schreiner; Ingrid B. Borecki; Michele K. Evans; Herman Taylor; Michele M. Sale; Virginia Howard; Christopher S. Ca...; Charles N. Rotimi; Mary Cushman; Tamara B. Harris; Alexander P. Reiner; L. Adrienne Cupples; Kari E. North; Caroline S. Fox
• Keywords: Genome-wide Association Study; Genetic genealogy; Genetic Association

Central obesity, measured by waist circumference (WC) or waist-hip ratio (WHR), is a marker of body fat distribution. Although obesity disproportionately affects minority populations, few studies have conducted genome-wide association study (GWAS) distribution among those predominantly African ancestry (AA). We performed GWAS WC and WHR, adjusted unadjusted for BMI, in up to 33,591 27,350 AA individuals, respectively. identified loci associated with individuals using meta-analyses GWA results WHR (stage 1). Overall, 25 SNPs single genomic control (GC)-corrected p-values<5.0×10−6 were followed-up 2) WHR. Additionally, we interrogated regions previously European (EA) AA. In joint analysis including both Stage 1 2 cohorts, demonstrated association, rs2075064 at LHX2, p = 2.24×10−8 WC-adjusted-for-BMI, rs6931262 RREB1, 2.48×10−8 WHR-adjusted-for-BMI. However, neither signal was significant after double GC-correction (LHX2: 6.5×10−8; RREB1: 5.7×10−8). Six fourteen reported EA populations (p<0.05 divided the number independent within region) studied here (TBX15-WARS2, GRB14, ADAMTS9, LY86, RSPO3, ITPR2-SSPN). Further, observed associations metabolic traits: rs13389219 GRB14 HDL-cholesterol, triglycerides, fasting insulin, rs13060013 ADAMTS9 HDL-cholesterol insulin. Finally, nominal evidence sexual dimorphism, stronger women locus (p interaction 0.02). conclusion, two suggestive addition confirming 6 EA. These findings reinforce concept that there are generalized adiposity.