Scribbled Optimizes BMP Signaling through Its Receptor Internalization to the Rab5 Endosome and Promote Robust Epithelial Morphogenesis

• DOI: 10.1371/journal.pgen.1006424
• Publication Date: 2016-11-04T17:33:10Z
• Authors: Jinghua Gui; Yunxian Huang; Osamu Shimmi
• Keywords: Decapentaplegic; Cell polarity; Internalization; Epithelial polarity; Polarity (international relations)

Epithelial cells are characterized by apical-basal polarity. Intrinsic factors underlying polarity crucial for tissue homeostasis and have often been identified to be tumor suppressors. Patterning differentiation of epithelia key processes epithelial morphogenesis frequently regulated highly conserved extrinsic factors. However, due the complexity morphogenesis, mechanisms precise interpretation signal transduction as well spatiotemporal control cues during dynamic remain poorly understood. Wing posterior crossvein (PCV) formation in Drosophila serves a unique model address how is secreted growth Decapentaplegic (Dpp), bone morphogenetic protein (BMP)-type ligand, directionally trafficked from longitudinal veins (LVs) into PCV region patterning differentiation. Our data reveal that basolateral determinant Scribbled (Scrib) required through optimizing BMP signaling. Scrib regulates BMP-type I receptor Thickveins (Tkv) localization at subsequently facilitates Tkv internalization Rab5 endosomes, where active. signaling also up-regulates scrib transcription pupal wing form positive feedback loop. mechanism which intrinsic genes coupled promote robust morphogenesis.