Voltage-gated calcium channels act upstream of adenylyl cyclase Ac78C to promote timely initiation of dendrite regeneration

• DOI: 10.1371/journal.pgen.1011388
• Publication Date: 2024-08-26T21:23:38Z
• Authors: J. Ian Hertzler; Jiajing Teng; Annabelle R. Bernard; Michelle C. Stone; Hannah L. Kline; Gibarni Mahata; Nitish Kumar; Melissa M. Rolls
• Keywords: Dendrite (mathematics)

Most neurons are not replaced after injury and thus possess robust intrinsic mechanisms for repair damage. Axon triggers a calcium wave, cAMP can augment axon regeneration. In comparison to regeneration, dendrite regeneration is poorly understood. To test whether might also be involved in signaling, we tracked the responses of Drosophila dendritic arborization laser severing axons dendrites. We found that subsequently accumulate cell body both injury. Two voltage-gated channels (VGCCs), L-Type T-Type, required influx response play role rapid initiation The AC8 family adenylyl cyclase, Ac78C, production timely Injury-induced sensitive VGCC reduction, placing upstream generation. propose two VGCCs initiate global followed by Ac78C. This signaling pathway promotes regrowth several hours