Real-world effectiveness of COVID-19 vaccines among Colombian adults: A retrospective, population-based study of the ESPERANZA cohort

• DOI: 10.1371/journal.pgph.0001845
• Publication Date: 2023-09-08T17:22:12Z
• Authors: Maylen Liseth Roj...; Julián Alfredo Fe...; Leonardo Arregocé...; Andrés Palacios-C...; Mariana Pinto-Álv...; Fernando Ruiz-Gómez
• Keywords: Booster dose; Booster (rocketry); Pandemic

COVID-19 vaccines have been essential for reducing the impact of pandemic; nevertheless, population-based data under real-life conditions are needed to compare their effectiveness in various contexts. The objective this study was estimate preventing hospitalization and death from Colombia among people aged 18 years older, according sex, age, confirmed history vaccination series, including effects boosters. This investigation an observational, retrospective, based on Colombian cohort “Esperanza”. A total 14,213,409 individuals older were analyzed, who matched a 1:1 ratio vaccinated unvaccinated. groups consisted unvaccinated individuals, those with complete series (CS) CS plus booster. received either homologous or heterologous vaccinations Ad26.COV2-S, BNT162b2, ChAdOx1 nCoV-19, CoronaVac mRNA-1273 vaccines. Follow-up conducted between February 2021 June 2022. Cox proportional hazards models used, adjusted potential confounders, different series. For adults overall 82.7% (95% CI 82.1–83.2) 80.2% (95%CI 78.7–81.6) + 86.0% 85.5–86.5) 83.1% 81.5–84.5) Effectiveness decreased age. While all efficacies high, offered significantly lower protection, although improved Continued mass is pivotal, especially low- middle-income countries. highlights both real-world these challenges understanding waning immunity influence VoC(Variants Concern) results.