RNA Editing Genes Associated with Extreme Old Age in Humans and with Lifespan in C. elegans

• DOI: 10.1371/journal.pone.0008210
• Publication Date: 2009-12-11T18:16:37Z
• Authors: Paola Sebastiani; Monty Montano; Annibale Puca; Nadia Solovieff; Toshio Kojima; Meng C. Wang; Efthymia Melista; Micah Meltzer; Sylvia E. J. Fischer; Stacy Andersen; Stephen H. Hartley; Amanda Sedgewick; Yasumichi Arai; Aviv Bergman; Nir Barzilai; Dellara F. Terry; Alberto Riva; Chiara Viviani An...; Alberto Malovini; Aya Kitamoto; Motoji Sawabe; Tomio Arai; Yasuyuki Gondo; Martin H. Steinberg; Nobuyoshi Hirose; Gil Atzmon; Gary Ruvkun; Clinton T. Baldwin; Thomas T. Perls
• Keywords: Adult; Male; 570; Adolescent; Genotype; Adenosine Deaminase; Science; Longevity; 610; Polymorphism, Single Nucleotide; Linkage Disequilibrium; 03 medical and health sciences; Gene Frequency; Odds Ratio; Animals; Humans; Caenorhabditis elegans; Genes, Helminth; Aged; Aged, 80 and over; 0303 health sciences; Chromosomes, Human, Pair 10; Q; R; Middle Aged; Medicine; Female; Algorithms; Research Article

The strong familiality of living to extreme ages suggests that human longevity is genetically regulated. majority genes found thus far be associated with primarily function in lipoprotein metabolism and insulin/IGF-1 signaling. There are likely many more genetic modifiers remain discovered.