Peritoneal Dialysis-Related Peritonitis Due to Staphylococcus aureus: A Single-Center Experience over 15 Years

• DOI: 10.1371/journal.pone.0031780
• Publication Date: 2012-02-21T22:50:37Z
• Authors: Pasqual Barretti; Taíse M. C. Moraes; Carlos H. Camargo; Jacqueline C. T. ...; Alessandro L. Mon...; Augusto C. Montelli; Maria de Lourdes ...
• Keywords: Adult; Male; 0301 basic medicine; Staphylococcus aureus; Virulence Factors; Science; Microbial Sensitivity Tests; Peritonitis; Young Adult; 03 medical and health sciences; Vancomycin; 616; Odds Ratio; Humans; Q; R; Middle Aged; 3. Good health; Logistic Models; Medicine; Female; Peritoneal Dialysis; Brazil; Research Article

Peritonitis caused by Staphylococcus aureus is a serious complication of peritoneal dialysis (PD), which associated with poor outcome and high PD failure rates. We reviewed the records 62 S. peritonitis episodes that occurred between 1996 2010 in unit single university hospital evaluated host bacterial factors influencing outcome. incidence was calculated for three subsequent 5-year periods compared using Poisson regression model. The production biofilm, enzymes, toxins evaluated. Oxacillin resistance based on minimum inhibitory concentration presence mecA gene. Logistic used analysis demographic, clinical, microbiological Resolution death rates were 117 contemporary coagulase-negative staphylococcus (CoNS) episodes. declined significantly over time from 0.13 1996–2000 to 0.04 episodes/patient/year 2006–2010 (p = 0.03). oxacillin rate 11.3%. Toxin enzyme expressive, except enterotoxin D. Biofilm positive 88.7% strains. gene higher frequency fever abdominal pain. logistic model showed diabetes mellitus 0.009) β-hemolysin 0.006) independent predictors non-resolution infection. probability resolution among patients aged 41 60 years than those >60 0.02). A trend observed (9.7%) CoNS (2.5%), 0.08), whereas similar. Despite decline incidence, remains rate. this infection negatively influenced such as age mellitus. In addition, predictive infection, suggesting pathogenic role factor PD-related peritonitis.