Bmp7 Regulates the Survival, Proliferation, and Neurogenic Properties of Neural Progenitor Cells during Corticogenesis in the Mouse

• DOI: 10.1371/journal.pone.0034088
• Publication Date: 2012-03-26T21:25:26Z
• Authors: Aikaterini Segklia; Eve Seuntjens; Maximilianos Elko...; Sotiris Tsalavos; Elke Stappers; Thimios A. Mitsiadis; Danny Huylebroeck; Eumorphia Rembout...; Daniel Graf
• Keywords: Corticogenesis; Conditional gene knockout; Progenitor; Ganglionic eminence

Bone morphogenetic proteins (BMPs) are considered important regulators of neural development. However, results mainly from a wide set in vitro gain-of-function experiments conflicting since these show that BMPs can act either as inhibitors or promoters neurogenesis. Here, we report specific and non-redundant role for BMP7 cortical neurogenesis vivo using knockout mice. Bmp7 is produced regions adjacent to the developing cortex; hem, meninges, choroid plexus, be detected cerebrospinal fluid. deletion reduced thickening, impaired neurogenesis, loss radial glia attachment meninges. Subsequent analyses E14.5 cells revealed lack affects progenitor cells, evidenced by their proliferation, survival self-renewal capacity. Addition was able rescue proliferation defects. In addition, at developmental stage also required maintain Ngn2 expression subventricular zone. These data demonstrate novel embryonic mouse cortex: nurtures regulates fundamental properties subsequently affect Ngn2-dependent