A Case-Control Study Estimating Accident Risk for Alcohol, Medicines and Illegal Drugs

• DOI: 10.1371/journal.pone.0043496
• Publication Date: 2012-08-28T21:52:10Z
• Authors: Kim Paula Colette...; Sara-Ann Legrand; Johannes Gerardus...; Alain Gaston Vers...
• Keywords: Adult; Male; Risk; Adolescent; Alcohol Drinking; Substance-Related Disorders; Science; ORAL FLUID; 03 medical and health sciences; 0302 clinical medicine; DRIVERS; Medicine and Health Sciences; Odds Ratio; Humans; Dronabinol; Cannabis; Illicit Drugs; Q; R; Accidents, Traffic; CANNABIS; Middle Aged; 3. Good health; Case-Control Studies; CRASHES; Medicine; Regression Analysis; Female; Research Article

The aim of the present study was to assess risk having a traffic accident after using alcohol, single drugs, or combination, and determine concentrations at which this is significantly increased.A population-based case-control carried out, collecting whole blood samples both cases controls, in number drugs were detected. an when under influence estimated logistic regression adjusting for gender, age time period (cases)/sampling (controls). main outcome measures odds ratio (OR) associated with multiple drug use. In total, 337 (negative: 176; positive: 161) 2726 controls 2425; 301) included study.Main findings that 1) alcohol general (all together) caused elevated crash risk; 2) cannabis also increase cut-off 2 ng/mL THC four times lowest concentrations; 3) ranking adjusted OR from highest risk, alone combination other related very stimulants combined sedatives.The demonstrated concentration-dependent positive drivers. Alcohol alcohol-drug combinations are by far most prevalent substances drivers subsequently pose largest traffic, terms scope.