Early Altered Resting-State Functional Connectivity Predicts the Severity of Post-Traumatic Stress Disorder Symptoms in Acutely Traumatized Subjects

• DOI: 10.1371/journal.pone.0046833
• Publication Date: 2012-10-02T23:19:28Z
• Authors: Yan Zhou; Zhen Wang; Ling-di Qin; Jie-qing Wan; Ya-wen Sun; Shan-shan Su; Wei-na Ding; Jian-rong Xu
• Keywords: Traumatic stress

The goal of this study was to investigate the relationship between resting-state functional connectivity and severity post-traumatic stress disorder (PTSD) symptoms in 15 people who developed PTSD following recent trauma. Fifteen participants experienced acute traumatic events underwent a 7.3-min resting magnetic resonance imaging scan within 2 days post-event. All patients were diagnosed with 1 6 months after Brain areas which activity correlated that posterior cingulate cortex (PCC) assessed. To assess PCC connectivity, contrast images representing positively subject's Clinician-Administered Scale scores (CAPS) when they diagnosed. Furthermore, PCC, medial prefrontal bilateral amygdala selected correlation strength CAPS. Resting state negatively CAPS left superior temporal gyrus right hippocampus/amygdala. amygdala, even could predict later. These results suggest early altered gyrus, hippocampus disease may be major risk factor predisposes develop PTSD.