Associations of BDNF Genotype and Promoter Methylation with Acute and Long-Term Stroke Outcomes in an East Asian Cohort

• DOI: 10.1371/journal.pone.0051280
• Publication Date: 2012-12-11T16:46:56Z
• Authors: Jae-Min Kim; Robert Stewart; Man-Seok Park; Hee-Ju Kang; Sung-Wan Kim; Il-Seon Shin; Hye-Ran Kim; Myung-Geun Shin; Ki-Hyun Cho; Jin-Sang Yoon
• Keywords: Stroke; rs6265

Brain derived neurotrophic factor (BDNF) has been shown to play an important role in poststroke recovery. BDNF secretion is influenced by genetic and epigenetic profiles. This study aimed investigate whether val66met polymorphism promoter methylation status were associated with outcomes at two weeks one year after stroke.A total of 286 patients evaluated the time admission stroke, 222 (78%) followed later order evaluate consequences stroke both acute chronic stages. Stroke dichotomised into good poor modified Rankin Scale. severity (National Institutes Health Scale), physical disability (Barthel Index), cognitive function (Mini-Mental State Examination) measured. Associations genotype on assessment scale scores investigated using logistic regression, repeated measures ANOVA partial correlation tests. was independently outcome 2 1 year, worsening over that period. Higher worse function. No significant genotype-methylation interactions found.A for recovery supported, clinical utility profile as prognostic biomarkers a target drug development suggested.