Cutoff Finder: A Comprehensive and Straightforward Web Application Enabling Rapid Biomarker Cutoff Optimization

• DOI: 10.1371/journal.pone.0051862
• Publication Date: 2012-12-14T22:17:40Z
• Authors: Jan Budczies; Frederick Klauschen; Bruno V. Sinn; Balázs Győrffy; Wolfgang D. Schmitt; Silvia Darb-Esfahani; Carsten Denkert
• Keywords: Cut-off

Gene or protein expression data are usually represented by metric at least ordinal variables. In order to translate a continuous variable into clinical decision, it is necessary determine cutoff point and stratify patients two groups each requiring different kind of treatment. Currently, there no standard method software for biomarker determination. Therefore, we developed Cutoff Finder, bundle optimization visualization methods determination that accessible online. While one the based solely on distribution marker under investigation, other optimize correlation dichotomization with respect an outcome survival variable. We illustrate functionality Finder analysis gene estrogen receptor (ER) progesterone (PgR) in breast cancer tissues. This these important markers analyzed correlated immunohistologically determined ER status distant metastasis free survival. expected fill relevant gap available biometric repertoire will enable faster new diagnostic biomarkers. The tool can be accessed http://molpath.charite.de/cutoff.