Circulation of Coxsackievirus A10 and A6 in Hand-Foot-Mouth Disease in China, 2009–2011

• DOI: 10.1371/journal.pone.0052073
• Publication Date: 2012-12-18T22:07:25Z
• Authors: Qing-Bin Lu; Xiao-Ai Zhang; Ying Wo; Hong-Mei Xu; Xiu-Jun Li; Xian-Jun Wang; Shu-Jun Ding; Xiao-Dan Chen; Cui He; Li-Juan Liu; Hao Li; Hong Yang; Ting-Yu Li; Wei Liu; Wu-Chun Cao
• Keywords: Coxsackievirus; Enterovirus 71; Hand-foot-and-mouth disease

Coxsackieviruses A10 (CV-A10) and A6 (CV-A6) have been associated with increasingly occurred sporadic hand-foot-mouth disease (HFMD) cases outbreak events globally. However, our understanding of epidemiological genetic characteristics these new agents remains far from complete. This study was to explore the circulation CV-A10 CV-A6 in HFMD their China. A hospital based surveillance performed three heavily inflicted regions March 2009 August 2011. Feces samples were collected children clinical diagnosis HFMD. The detection genotyping enteroviruses by real-time PCR sequencing 5′UTR/VP1 regions. Phylogenetic analysis selection pressure on VP1 sequences. Logistic regression model used identify effect predominant enterovirus serotypes causing severe results showed 92.0% 1748 feces detected positive for enterovirus, most frequently presented as EV-71 (944, 54.0%) CV-A16 (451, 25.8%). a sole pathogen 82 (4.7%) 44 (2.5%) cases, respectively. Infection independently high risk (OR = 2.66, 95% CI: 1.40–5.06; OR 4.81, 3.07–7.53), when adjusted age sex. revealed that distinct geographic temporal origins correlated gene clusters An overall ω value 0.046 0.047 CV-A6, no positively selected site both indicating purifying shaped evolution CV-A6. Our demonstrates variety genotypes viral pathogens co-circulating together recent years. infection might also be