Association of Single Nucleotide Polymorphisms in TCF2 with Type 2 Diabetes Susceptibility in a Han Chinese Population

• DOI: 10.1371/journal.pone.0052938
• Publication Date: 2012-12-31T17:25:56Z
• Authors: Xuelong Zhang; Hong Qiao; Yanling Zhao; Xi Wang; Haiming Sun; An Liu; Lidan Xu; Donglin Sun; Yan Jin; Yang Yu; Xiangning Meng; Jing Bai; Feng Chen; Songbin Fu
• Keywords: Adult; Male; China; Genotype; Science; Polymorphism, Single Nucleotide; 03 medical and health sciences; Asian People; Gene Frequency; Humans; Genetic Predisposition to Disease; Alleles; Genetic Association Studies; Aged; Hepatocyte Nuclear Factor 1-beta; 0303 health sciences; Q; R; Middle Aged; 3. Good health; Diabetes Mellitus, Type 2; Haplotypes; Medicine; Female; Research Article

Hepatocyte nuclear factor 1β (HNF1β), a transcription encoded by the 2 gene (TCF2), plays critical role in pancreatic cell formation and glucose homeostasis. It has been suggested that single nucleotide polymorphisms (SNPs) of TCF2 are associated with susceptibility to type diabetes (T2D). However, published results inconsistent inclusive. To further investigate these common variants, we examined association risk T2D Han population northeastern China. We genotyped five SNPs 624 patients 630 healthy controls using SNaPshot method, evaluated conferred individual haplotypes. In single-locus analysis, found rs752010, rs4430796 rs7501939 showed allelic differences between controls, an OR 1.26 (95% CI 1.08–1.51, P = 0.003), 1.23 1.06–1.55, 0.001) 1.28 1.10–1.61, 0.001), respectively. Genotype analysis each locus also revealed homozygous carriers at-risk allele had significant increased compared other (OR 1.78, 95% 1.20–2.64 for rs752010; 1.82, 1.24–2.67 rs4430796; 1.95, 1.31–2.90 rs7501939), even after Bonferroni correction multiple comparisons. Besides, haplotype-based demonstrated AGT block rs752010-rs4430796-rs7501939 was about 30% increase 1.31, 1.09–1.57, 0.01). Our findings variants may be involved Larger studies ethnically diverse populations warranted confirm reported this investigation.