Diacylglycerol Acyltransferase-1 (DGAT1) Inhibition Perturbs Postprandial Gut Hormone Release

• DOI: 10.1371/journal.pone.0054480
• Publication Date: 2013-01-15T22:24:47Z
• Authors: Hua V. Lin; Dunlu Chen; Zhu Shen; Lei Zhu; Xuesong Ouyang; Aurawan Vongs; Yanqing Kan; John M. Levorse; Edward J. Kowalik; Daphne M. Szeto; Xiaorui Yao; Jianying Xiao; Shirley Chen; Jinqi Liu; Marga Garcia-Calvo; Myung K. Shin; Shirly Pinto
• Keywords: Peptide YY

Diacylglycerol acyltransferase-1 (DGAT1) is a potential therapeutic target for treatment of obesity and related metabolic diseases. However, the degree DGAT1 inhibition required benefits unclear. Here we show that partial deficiency in mice suppressed postprandial triglyceridemia, led to elevations glucagon-like peptide-1 (GLP-1) peptide YY (PYY) only following meals with very high lipid content, did not protect from diet-induced obesity. Maximal enhanced GLP-1 PYY secretion physiologically relevant content. Finally, combination dipeptidyl-peptidase-4 (DPP-4) further enhancements active dogs. The current study suggests targeting enhance gut hormone requires maximal inhibition, DPP-4i as strategy develop inhibitors