Time Course of Current of Injury Is Related to Acute Stability of Active-Fixation Pacing Leads in Rabbits

• DOI: 10.1371/journal.pone.0057727
• Publication Date: 2013-03-05T17:31:03Z
• Authors: Shalaimaiti Shali; Alimujiang Wushou; Entao Liu; Lin Jia; Ruiming Yao; Yangang Su; Junbo Ge
• Keywords: Lead (geology)

Background Magnitude of current injury (COI) consequent to pacemaker lead fixation is recognized as a predictor acute stability. It unclear whether dynamic monitoring COI after provides additional information beyond single assessment performed at the time fixation. Objectives This study was aimed test hypothesis that course related Methods and Results Active leads with fixed screw were anchored either Langendorff-perfused rabbit hearts endocardially or in vivo epicardially manners contact helix no rotation, half rotation full respectively. Intracardiac electrogram (EGM) monitored dynamically from onset resolution COI, magnitudes intrinsic R wave including ST-segment elevation, ST/R intracardiac EGM duration (IED), measured. A digital force gauge applied assess In vitro, contacted significantly smaller than those rotated (p<0.05) fully (p<0.05), presented most precipitous recovery baseline (1.5±1.1 min, p<0.05). Half-rotated manifested same magnitude right placement. However, longer (26.5±2.8 min vs. 5.6±2.0 Similar findings observed vivo. The correlated needed detach myocardium (r = 0. 72, n 48, p<0.001). Conclusions Time stability rabbits. One might be misled by placement, whereas persistence likely useful indicator adequate