Comparative Genomic Analysis of the Genus Nocardiopsis Provides New Insights into Its Genetic Mechanisms of Environmental Adaptability

• DOI: 10.1371/journal.pone.0061528
• Publication Date: 2013-04-23T21:53:22Z
• Authors: Hong-Wei Li; Xiao-Yang Zhi; Ji-Cheng Yao; Yu Zhou; Shu-Kun Tang; Hans-Peter Klenk; Jiao Zhao; Wen-Jun Li
• Keywords: Adaptability

The genus Nocardiopsis, a widespread group in phylum Actinobacteria, has received much attention owing to its ecological versatility, pathogenicity, and ability produce rich array of bioactive metabolites. Its high environmental adaptability might be attributable genome dynamics, which can estimated through comparative genomic analysis targeting microorganisms with close phylogenetic relationships but different phenotypes. To shed light on speciation, gene content evolution, adaptation these unique actinobacteria, we sequenced draft genomes for 16 representative species the compared them that type N. dassonvillei subsp. DSM 43111T. core 1,993 orthologous paralogous clusters was identified, pan-genomic reservoir found not only accommodate more than 22,000 genes, also open. top ten genes terms copy number could referred three functional categories: transcription regulators, transporters, synthases related Based phylogenomic reconstruction, inferred past evolutionary events, such as gains losses, identified list clade-specific implicated adaptation. These results provided insights into genetic causes this cosmopolitan actinobacterial contributions made by inherent features, including dynamics constituents accessory proteins.