Systemic Down-Regulation of Delta-9 Desaturase Promotes Muscle Oxidative Metabolism and Accelerates Muscle Function Recovery following Nerve Injury

• DOI: 10.1371/journal.pone.0064525
• Publication Date: 2013-06-13T21:18:30Z
• Authors: Ghulam Hussain; Florent Schmitt; Alexandre Henriques; Thiebault Lequeu; Frederique Rene; Françoise Bindler; Sylvie Dirrig-Grosch; Hugues Oudart; Lavinia Palamiuc; Marie-Helene Metz...; Luc Dupuis; Eric Marchioni; Jose-Luis Gonzale...; Jean-Philippe Loe...
• Keywords: Hypermetabolism

The progressive deterioration of the neuromuscular axis is typically observed in degenerative conditions lower motor neurons, such as amyotrophic lateral sclerosis (ALS). Neurodegeneration this disease associated with systemic metabolic perturbations, including hypermetabolism and dyslipidemia. Our previous gene profiling studies on ALS muscle revealed down-regulation delta-9 desaturase, or SCD1, which rate-limiting enzyme synthesis monounsaturated fatty acids. Interestingly, knocking out SCD1 known to induce stimulate acid beta-oxidation. Here we investigated whether deficiency can affect function its restoration response injury. genetic ablation was not detrimental per se function. On contrary, muscles knockout mice shifted toward a more oxidative metabolism, enhanced expression synaptic genes. Repressing reducing SCD-dependent enzymatic activity accelerated recovery after inducing sciatic nerve crush. Overall, these findings provide evidence for new role modulating restorative potential skeletal muscles.