Genome-Wide Association Analyses for Fatty Acid Composition in Porcine Muscle and Abdominal Fat Tissues

• DOI: 10.1371/journal.pone.0065554
• Publication Date: 2013-06-08T15:05:39Z
• Authors: Bin Yang; Wanchang Zhang; Zhiyan Zhang; Yin Fan; Xianhua Xie; Huashui Ai; Junwu Ma; Shijun Xiao; Lusheng Huang; Jun Ren
• Keywords: Genome-wide Association Study; Genetic Association

Fatty acid composition is an important phenotypic trait in pigs as it affects nutritional, technical and sensory quality of pork. Here, we reported a genome-wide association study (GWAS) for fatty the longissimus muscle abdominal fat tissues 591 White Duroc×Erhualian F2 animals samples 282 Chinese Sutai pigs. A total 46 loci surpassing suggestive significance level were identified on 15 pig chromosomes (SSC) 12 acids, revealing complex genetic architecture Of loci, SSC5, 7, 14 16 reached level. The two most significant SNPs ss131535508 (P = 2.48×10(-25)) at 41.39 Mb SSC16 C20∶0 ss478935891 3.29×10(-13)) 121.31 SSC14 C18∶0. meta-analysis GWAS 4 novel enhanced strength 6 compared to those evidenced single population, suggesting presence common underlying variants. showed consistent profiles distinct signals several loci. All have specific effects composition, except SSC4 SSC7 affecting multiple fatness traits. Several promising candidate genes found neighboring regions lead such SCD C18∶0 C16∶1 ELOVL7 SSC16. findings provide insights into molecular basis pigs, would benefit final identification mutations.