Effect of Acute Exercise on Prostate Cancer Cell Growth

• DOI: 10.1371/journal.pone.0067579
• Publication Date: 2013-07-05T17:12:41Z
• Authors: Helene Rundqvist; Martin Augsten; Anna Strömberg; Eric Rullman; Sara Mijwel; Pedram Kharaziha; Theocharis Panare...; Thomas Gustafsson; Arne Östman
• Keywords: Physical exercise

Physical activity is associated with reduced risk of several cancers, including aggressive prostate cancer. The mechanisms mediating the effects are not yet understood; among candidates modifications endogenous hormone levels. Long-term exercise known to reduce serum levels growth stimulating hormones. In contrast, endocrine acute endurance include increased mitogenic factors such as GH and IGF-1. It can be speculated that elevation may detrimental cancer progression into malignancy. incentive current study evaluate effect on cell growth. We designed an intervention where 10 male individuals performed 60 minutes bicycle at increasing intensity. Serum samples were obtained before (rest serum) after completed (exercise serum). established line LNCaP was exposed or rest serum. Exercise from 9 out had a inhibitory cells. Incubation pooled resulted in 31% inhibition pre-incubation subcutaneous injection SCID mice caused delay tumor formation. analyses indicated two possible for effect; IGFBP-1 EGF. conclusion, despite fear growth, we show even short-term seem add overall beneficial influence neoplasia.