A Higher Risk of Acute Rejection of Human Kidney Allografts Can Be Predicted from the Level of CD45RC Expressed by the Recipients’ CD8 T Cells

• DOI: 10.1371/journal.pone.0069791
• Publication Date: 2013-07-24T23:34:07Z
• Authors: Laurence Ordonez; Isabelle Bernard; Marianne Chabod; Jean-François Aug...; Valerie Lauwers-C...; Christelle Cristini; Maria-Cristina Cu...; Jean-François Subra; Abdelhadi Saoudi
• Keywords: Transplant rejection

Although transplantation is the common treatment for end-stage renal failure, allograft rejection and marked morbidity from use of immunosuppressive drugs remain important limitations. A major challenge in field to identify easy, reliable noninvasive biomarkers allowing prediction deleterious alloreactive immune responses tailoring therapy individuals according risk. In this study, we first established that expression RC isoform CD45 molecule (CD45RC) on CD4 CD8 T cells healthy identifies functionally distinct cell subsets behave differently terms proliferation cytokine secretion. We then investigated whether frequency recipients CD45RC before would predict acute graft a cohort 89 patients who had undergone their kidney transplantation. showed exhibiting more than 54.7% CD45RC(high) 6 fold increased risk rejection. contrast, proportions were not predictive. Thus, higher human allografts can be predicted level expressed by recipients' cells.