FOXP3 Subcellular Localization Predicts Recurrence in Oral Squamous Cell Carcinoma

• DOI: 10.1371/journal.pone.0071908
• Publication Date: 2013-08-21T02:02:17Z
• Authors: Donald T. Weed; Gail Walker; Adriana C. De La ...; Ronen Nazarian; Jennifer L. Vella; Carmen R. Gomez-F...; Paolo Serafini
• Keywords: Adult; CD4-Positive T-Lymphocytes; Male; Science; 03 medical and health sciences; 0302 clinical medicine; Risk Factors; Biomarkers, Tumor; Humans; Aged; Retrospective Studies; Aged, 80 and over; Cell Nucleus; Q; R; Forkhead Transcription Factors; Middle Aged; Prognosis; 3. Good health; Protein Transport; ROC Curve; Case-Control Studies; Carcinoma, Squamous Cell; Medicine; Female; Mouth Neoplasms; Neoplasm Recurrence, Local; Research Article

Forkhead box protein P3 (FOXP3) expression in tumor infiltrating CD4+T cells is generally associated with an intrinsic capacity to suppress immunity. Based on this notion, different studies have evaluated the prognostic value of maker cancer but contradictory results been found. Indeed, even within same population, presence CD4+FOXP3+T has associated,with either a poor or good prognosis, no correlation beenfound. Here, we demonstrate,in patients oral squamous cell carcinoma (OSCC), that what really represents parameter not overall FOXP3 its intracellular localization.While overallFOXP3 does correlate recurrence, localization CD4 does: nuclear (nFOXP3) recurrence 3 years, while cytoplasmicFOXP3 (cFOXP3) lower likelihood recurrence. Thus, propose elevated levels cFOXP3/nFOXP3 ratio CD4+ T as predictor OSCC