New Avian Paramyxoviruses Type I Strains Identified in Africa Provide New Outcomes for Phylogeny Reconstruction and Genotype Classification

• DOI: 10.1371/journal.pone.0076413
• Publication Date: 2013-10-18T21:15:08Z
• Authors: Renata Servan de ...; Saliha Hammoumi; Patricia Gil; François-Xavier B...; Sophie Molia; Nicolas Gaidet; Julien Cappelle; Véronique Chevalier; Gilles Balança; Abdallah Traoré; Colette Grillet; Olivier Fridolin ...; Samia Guendouz; Marthin Dakouo; Kassim Samaké; Ould El Mamy Bezeid; Abbas Diarra; Hassen Chaka; Flavie Goutard; Peter Thompson; Dominique Martinez; Véronique Jestin; Emmanuel Albina
• Keywords: 0301 basic medicine; Newcastle disease virus (NDV); [SDV]Life Sciences [q-bio]; L73 - Maladies des animaux; 630; http://aims.fao.org/aos/agrovoc/c_16411; http://aims.fao.org/aos/agrovoc/c_5567; African domestic and wild birds; évolution; http://aims.fao.org/aos/agrovoc/c_3225; Avulavirus; Avian paramyxoviruses; http://aims.fao.org/aos/agrovoc/c_4510; surveillance épidémiologique; http://aims.fao.org/aos/agrovoc/c_5166; Phylogeny; Q; http://aims.fao.org/aos/agrovoc/c_27583; http://aims.fao.org/aos/agrovoc/c_165; R; Newcastle disease (ND); Poultry -- Virus diseases; http://aims.fao.org/aos/agrovoc/c_4540; classification; Paramyxoviridae; http://aims.fao.org/aos/agrovoc/c_16022; Medicine; RNA, Viral; génotype; Research Article; 570; http://aims.fao.org/aos/agrovoc/c_28665; Genotype; Science; Newcastle Disease; provenance; Genome, Viral; animal sauvage; http://aims.fao.org/aos/agrovoc/c_24103; http://aims.fao.org/aos/agrovoc/c_935; Evolution, Molecular; 03 medical and health sciences; phylogénie; oiseau; Animals; http://aims.fao.org/aos/agrovoc/c_2676; http://aims.fao.org/aos/agrovoc/c_13325; Poultry Diseases; Avulavirus Infections; http://aims.fao.org/aos/agrovoc/c_2745; séquence nucléotidique; volaille; Enquête pathologique; Paramyxoviruses; Africa; virus maladie de newcastle; http://aims.fao.org/aos/agrovoc/c_1653; http://aims.fao.org/aos/agrovoc/c_6145

Newcastle disease (ND) is one of the most lethal diseases poultry worldwide. It caused by an avian paramyxovirus 1 that has high genomic diversity. In framework international surveillance program launched in 2007, several thousand samples from domestic and wild birds Africa were collected analyzed. ND viruses (NDV) detected isolated apparently healthy fowls birds. However, two thirds isolates this study classified as virulent strains NDV based on molecular analysis fusion protein experimental vivo challenges with representative isolates. Phylogenetic F HN genes showed recovered Mali Ethiopia form new groups, herein proposed genotypes XIV sub-genotype VIf reference to nomenclature described Diel's group. Madagascar, circulation genotype XI, originally reported elsewhere, also confirmed. Full genome sequencing five African was generated extensive phylogeny reconstruction carried out nucleotide sequences. The evolutionary distances between groups specific amino acid signatures each cluster allowed us refine nomenclature.