Microbial Dysbiosis Is Associated with Human Breast Cancer

• DOI: 10.1371/journal.pone.0083744
• Publication Date: 2014-01-08T21:49:02Z
• Authors: Caiyun Xuan; Jaime M. Shamonki; Alice Chung; Maggie L. DiNome; Maureen Chung; Peter A. Sieling; Delphine J. Lee
• Keywords: Dysbiosis

Breast cancer affects one in eight women their lifetime. Though diet, age and genetic predisposition are established risk factors, the majority of breast cancers have unknown etiology. The human microbiota refers to collection microbes inhabiting body. Imbalance microbial communities, or dysbiosis, has been implicated various diseases including obesity, diabetes, colon cancer. Therefore, we investigated potential role by next-generation sequencing using tumor tissue paired normal adjacent from same patient. In a qualitative survey DNA, found that bacterium Methylobacterium radiotolerans is relatively enriched tissue, while Sphingomonas yanoikuyae tissue. relative abundances these two bacterial species were inversely correlated but not indicating dysbiosis associated with Furthermore, total DNA load was reduced versus healthy as determined quantitative PCR. Interestingly, advanced disease, finding could broad implications diagnosis staging Lastly, observed lower basal levels antibacterial response gene expression Taken together, data indicate present bacteria components may influence local immune microenvironment. Our findings suggest previously unrecognized link between which diagnostic therapeutic implications.