Relationship between Changes in Body Fat and a Decline of Renal Function in the Elderly

• DOI: 10.1371/journal.pone.0084052
• Publication Date: 2014-01-16T21:21:59Z
• Authors: Se Won Oh; Shin Young Ahn; Xu Jianwei; Ki Woong Kim; Sejoong Kim; Ki Young Na; Dong Wan Chae; Suhnggwon Kim; Ho Jun Chin
• Keywords: Bioelectrical Impedance Analysis

Obesity is a risk factor for chronic kidney disease, and its prevalence among the elderly increasing. We investigated effects of changes in body fat percentage (BFP) on longitudinal estimated glomerular filtration rate (eGFR) elderly. This prospective cohort study included 390 participants aged >65 years who underwent bioelectrical impedance analysis at baseline follow-up as part Korean Longitudinal Study Health Aging. After median period 5.3 years, BFP was significantly higher than that start point (P<0.05). Participants had largest increase highest BMI waist circumference (WC) (P<0.001). The tertile white blood cell count erythrocyte sedimentation rate, incidence rapid progression, decline eGFR >25% (P≤0.017, P = 0.025, 0.005, respectively). lowest triglyceride high-density lipoprotein levels adjusted correlated with change (P 0.039), but not or WC. 4.875-fold progression to (95% CI: 1.366–17.397) 4.931-fold decrease eGFR>25% 1.617–15.037), when compared tertile. In subgroup analysis, renal outcomes increased according patients lower (P≤0.010). A may be associated inflammation dyslipidemia development, are related