Effects Of A Post-Weaning Cafeteria Diet In Young Rats: Metabolic Syndrome, Reduced Activity And Low Anxiety-Like Behaviour

• DOI: 10.1371/journal.pone.0085049
• Publication Date: 2014-01-15T21:25:10Z
• Authors: Jaume F. Lalanza; Antoni Caimari; Josep M. del Bas; Daniel Torregrosa; Igor Cigarroa; Mercè Pallàs; Lluís Capdevila; Lluís Arola; Rosa M. Escorihuela
• Keywords: Cafeteria; Elevated plus maze

Among adolescents, overweight, obesity and metabolic syndrome are rapidly increasing in recent years as a consequence of unhealthy palatable diets. Animal models diet-induced have been developed, but little is known about the behavioural patterns produced by consumption such The aim present study was to determine biochemical effects cafeteria diet fed juvenile male female rats, well evaluate possible recovery from these administering standard feeding during last week study. Two groups rats were with either chow (ST) or (CAF) weaning for 8 weeks. A third group males (CAF withdrawal) CAF 7 weeks ST 8th week. Both females developed feeding, showing higher adiposity liver weight, increased plasma levels glucose, insulin triglycerides, resistance, comparison their respective controls. reduced motor activity all tests, enhanced exploration, anxiety-like behaviour social interaction; this effect more pronounced than males. When compared animals only diet, withdrawal anxiety open field, slightly decreased body completely recovered sensitivity triglycerides plasma. In conclusion, young induced syndrome, robust changes adult whereas modestly anxiety, reversed alterations partially overweight.