Increased Ndfip1 in the Substantia Nigra of Parkinsonian Brains Is Associated with Elevated Iron Levels

• DOI: 10.1371/journal.pone.0087119
• Publication Date: 2014-01-24T21:40:46Z
• Authors: Jason Howitt; Amanda M. Gysbers; Scott Ayton; Francine Carew-Jones; Ulrich Putz; David I. Finkelstein; Glenda M. Halliday; Seong-Seng Tan
• Keywords: DMT1

Iron misregulation is a central component in the neuropathology of Parkinson's disease. The iron transport protein DMT1 known to be increased brains linking functional mechanisms with accumulation. regulation therefore critical management uptake disease setting. We previously identified post-translational control levels through ubiquitin-mediated pathway led by Ndfip1, an adaptor for Nedd4 family E3 ligases. Here we show that loss Ndfip1 from mouse dopaminergic neurons resulted and susceptibility induced death. report human concentrations substantia nigra are associated upregulated containing α-synuclein deposits. Additionally, was also found misexpressed astrocytes, cell type normally devoid this protein. suggest disease, expression DMT1, including abnormal activation non-neuronal types such as astrocytes.