Detection of Human Papillomavirus Infection and p16 Immunohistochemistry Expression in Bladder Cancer with Squamous Differentiation

• DOI: 10.1371/journal.pone.0093525
• Publication Date: 2014-03-27T17:15:51Z
• Authors: Sung Han Kim; Jae Young Joung; Jinsoo Chung; Weon Seo Park; Kang Hyun Lee; Ho Kyung Seo
• Keywords: Squamous metaplasia

Objectives To determine the potential association between HPV infection and squamous cell component of urothelial carcinoma (UC) bladder to validate p16 overexpression as a surrogate marker for in these cancers among Koreans. Methods We analyzed presence using an HPV-DNA chip expression immunohistochemistry 47 subjects July 2001 March 2011. The study group (n = 35) included patients with differentiation UC bladder. control 12) metaplasia Results Baseline characteristics groups were similar. DNA detection rates approximately 2-fold higher than (17.1% [6/35] versus 8.3% [1/12], respectively), but difference was not statistically significant. P16 detected 16/35 (45.7%) 1/12 (8.3%) samples (p 0.034). Both HPV-positivity present 3/35 (8.8%) samples, none 0.295). In group, percentage HPV-positive cases who non-smokers HPV-negative (66.7% [4/6] 31.0% [9/29], respectively); however, statistical significance achieved due small sample size. Conclusions may be associated differentiation, especially non-smokers. However, does appear strong evidence this type cancer.