Persistence of IgE-Associated Allergy and Allergen-Specific IgE despite CD4+ T Cell Loss in AIDS

• DOI: 10.1371/journal.pone.0097893
• Publication Date: 2014-06-04T16:20:50Z
• Authors: Katharina Marth; Eva Wollmann; Daniela Gallerano; Portia Ndlovu; Ian Makupe; Rudolf Valenta; Elopy Sibanda
• Keywords: Adult; CD4-Positive T-Lymphocytes; Male; Acquired Immunodeficiency Syndrome; Science; Q; R; HIV Infections; Middle Aged; Rhinitis, Allergic; Asthma; CD4 Lymphocyte Count; 3. Good health; Acquired Immunodeficiency Syndrome; Adult; Aged; Asthma; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Female; HIV Infections; Humans; Male; Middle Aged; Rhinitis, Allergic; Agricultural and Biological Sciences (all); Biochemistry, Genetics and Molecular Biology (all); Medicine (all); 03 medical and health sciences; 0302 clinical medicine; Medicine; Humans; Female; Research Article; Aged

The infection of CD4+ cells by HIV leads to the progressive destruction T lymphocytes and, after a severe reduction cells, AIDS. aim study was investigate whether HIV-infected patients with CD4 cell counts <200 cells/µl can suffer from symptoms IgE-mediated allergy, produce allergen-specific IgE antibody responses and show boosts production. ≤200 suffering AIDS allergy were studied. Allergy diagnosed according case history, physical examination, skin prick testing (SPT), serological analyses including allergen microarrays. confirmed serologically disease staged clinically. predominant allergic in studied acute rhinitis (73%) followed asthma (27%) due mast activation whereas no late phase such as atopic dermatitis, mainly cell-mediated manifestation, found According serology allergies house dust mites grass pollen most common besides sensitizations various food allergens. Interestingly, levels additional ten IgE-sensitized infections low appeared be boosted seasonal exposure not associated counts. Our results indicate that secondary production inflammation do require fully functional lymphocyte repertoire.