Multinucleation during C. trachomatis Infections Is Caused by the Contribution of Two Effector Pathways

• DOI: 10.1371/journal.pone.0100763
• Publication Date: 2014-06-23T20:36:34Z
• Authors: Heather M. Brown; Andrea E. Knowlton; Emily Snavely; Bidong D. Nguyen; Theresa S. Richards; Scott S. Grieshaber
• Keywords: Obligate

Chlamydia trachomatis is an obligate intracellular bacterial pathogen and the second leading cause of sexually transmitted infections in US. Infections significant morbidity can lead to serious reproductive sequelae, including epidemiological link increased rates cancers. One overt changes that infected cells exhibit development genomic instability multinucleation. Here we demonstrate induction multinucleation not conserved equally across chlamydial species; C. L2 caused high levels multinucleation, muridarum intermediate levels, caviae had very modest effects on Our data show at least two effector pathways together during infection We find highly protease CPAF a key for one these pathways. secretion required loss centrosome duplication regulation as well inducing early mitotic exit. The pathway involves position errors. This function three species tested. Together contribute seen infections.